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慢性肾功能不全性高血压是临床常见的难治性高血压,是肾功能不全晚期患者主要死亡原因之一。本文共观察34例慢性肾功能不全患者,均为1985～1988年内科住院病人。血压平均26±3.4/16.7±2.6kPa,分为2组,一组17例进行口服哌唑嗪,心得安加利尿剂,另一组使用复方降压片进行对比分析。方法:哌唑嗪组:哌唑嗪首剂口服1.5～3 mg/d,逐渐增加到6～15 mg/d,分3次服用,同时服心得安30～60mg/d,尿少时加用速尿,保证患者每日尿量不低于1000 ml,对照组复方降压片6片/d,分3次口服,一般加用利尿剂双氢克尿噻25 mg,一日3次。观察2组治疗前后收缩压,舒张压,获最大降压时间以及治疗前后肾功能的变化。结果:哌唑嗪组有效为88.2％,复方片组为32.8％,两组疗效有显著性差异
Chronic renal insufficiency (Hypertension) is one of the major causes of death in patients with advanced renal dysfunction. In this paper, a total of 34 patients with chronic renal insufficiency were observed, all from 1985 to 1988 inpatient inpatient medicine. Blood pressure average 26 ± 3.4 / 16.7 ± 2.6kPa, divided into two groups, a group of 17 cases of oral prazosin, the experience of urinary diuretics, the other group using the compound antihypertensive tablets for comparative analysis. Prazosin group: Prazosin the first dose of oral 1.5 ~ 3 mg / d, gradually increased to 6 ~ 15 mg / d, taking 3 times, at the same time serving propranolol 30 ~ 60mg / d, Urine, to ensure that patients with daily urine output of not less than 1000 ml, the control group compound antihypertensive tablets 6 / d, 3 times orally, usually with diuretics hydrochlorothiazide 25 mg, 3 times a day. The changes of systolic blood pressure, diastolic blood pressure, maximum blood pressure depressing time and renal function before and after treatment were observed in two groups before and after treatment. Results: The effective rate of prazosin group was 88.2% and that of Fufang Tablet group was 32.8%, the curative effect was significant difference between the two groups