论文部分内容阅读
硫酸镁(MgSO_4)在试管内具有平滑肌松弛作用,在缓解支气管哮喘方面,许多病例报道及无对照组研究证明其安全、有效,但近年来一些临床对照试验对其效果提出疑问。本研究以随机、双盲、安慰剂对照试验的方法,评定标准治疗基础上加用MgSO_4治疗急性哮喘加重患者的效果。 方法 选择1990～1991年就诊于急诊室的急性哮喘患者,年龄18～65岁,FEV_1(1秒最大呼气量低于75%预期值,排除充血性心衰,糖尿病、心绞痛、慢性肾功能不全,肺炎、妊娠,体温不超过38℃。对所选病例行随机双盲安慰剂对照试验。在急性哮喘给予标准治疗30分钟的基础上,对所选患者随机给予静脉输入
Magnesium sulfate (MgSO_4) has a smooth muscle relaxation effect in the test tube. In relieving bronchial asthma, many cases reported and no control group studies have proved its safety and effectiveness. However, some clinical trials have raised questions about its efficacy in recent years. In this study, randomized, double-blind, placebo-controlled trial to assess the standard treatment based on the effect of adding MgSO 4 in patients with exacerbations of acute asthma. Methods Acute asthma patients aged 18-65 years old who were admitted to the emergency room from 1990 to 1991 were enrolled in this study. FEV 1 (maximal expiratory volume less than 75% at one second, excluding congestive heart failure, diabetes, angina pectoris, chronic renal insufficiency , Pneumonia, pregnancy, body temperature does not exceed 38 ° C. Randomized double-blind placebo-controlled trials of selected patients on the basis of acute asthma in the standard treatment for 30 minutes on the basis of selected patients were randomly given intravenous input