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目的:探讨柴胡四黄汤对重症急性胰腺炎(SAP)血清细胞因子水平的影响。方法:60例SAP病患者随机分为治疗组和对照组(各30例)。治疗组给予柴胡四黄汤口服,1剂/d;对照组30例,给予大柴胡汤口服,1次/d,疗程均为7 d。测定两组患者治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和白细胞介素10(IL-10)水平。且设正常健康组30例。结果:2组IL-10水平均较健康组低。而TNF-α及IL-6较健康组高(P<0.01)。治疗后治疗组TNF-,αIL-6水平与对照组比明显降低(P<0.01),IL-10与对照组比明显增高(P<0.01),治疗组与治疗前对比P<0.01。结论:柴胡四黄汤能显著调节细胞因子水平,促进SAP早期恢复。
Objective: To investigate the effect of Chaihu Sihuang Decoction on serum cytokines in patients with severe acute pancreatitis (SAP). Methods: Sixty patients with SAP were randomly divided into treatment group and control group (30 cases each). The treatment group was given Chaihu Shuang Decoction orally, 1 / d; control group of 30 cases, given Dachaihu Tang orally, 1 / d, treatment were 7 d. The levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interleukin 10 (IL-10) were measured before and after treatment in both groups. And set the normal health group of 30 cases. Results: The levels of IL-10 in both groups were lower than those in healthy group. While the levels of TNF-α and IL-6 were higher in healthy group (P <0.01). After treatment, the levels of TNF-α and αIL-6 in the treatment group were significantly lower than those in the control group (P <0.01), while the levels of IL-10 in the treatment group were significantly higher than those in the control group (P <0.01). Conclusion: Chaihu Sihuang Decoction can significantly regulate the levels of cytokines and promote the early recovery of SAP.