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2例慢性肾功能不全患者因肺部感染使用头孢吡肟致相关脑病。例1,56岁女性患者,给予头孢吡肟2.0g,2次/d静脉滴注。2d后患者表情淡漠、认知障碍、行为异常、失眠、肢体不自主震颤。第4天症状加重,脑电图示持续慢波,频繁出现的三相波。立即停用头孢吡肟,行血液透析,2d后症状好转。例2,22岁男性患者,给予头孢吡肟2.0g,1次/8h静脉滴注。用药第5天,出现言语和行为异常,认知障碍、肢体不自主震颤。停用头孢吡肟,行血液透析治疗2d后,症状消失。
2 cases of patients with chronic renal failure using cefepime-induced encephalopathy due to pulmonary infection. Example 1,56-year-old female patients were given cefepime 2.0g, 2 times / d intravenous infusion. 2d after the patient’s expression of indifference, cognitive disorders, abnormal behavior, insomnia, limb involuntary tremors. Day 4 symptoms worse, EEG continued slow wave, frequent three-phase wave. Immediately disable cefepime, hemodialysis, 2d after the symptoms improved. Example 2,22-year-old male patients were given cefepime 2.0g, 1 / 8h intravenous infusion. On the fifth day of treatment, abnormal speech and behavior, cognitive impairment and involuntary limb tremor appeared. Cefepime discontinuation, after hemodialysis treatment 2d, the symptoms disappear.