In this work, pure Nb, Nb5Si3 and Laves Cr2Nb compound powders were used as raw materials to prepare Nb-Si- Cr tary alloys by spark plasma sintering (SPS). A comprehensive estimation of the microstructure and properties, including room temperature fracture toughness, high temperature strength and oxidation resistance, of the Nb-Si-Cr tary alloys as a function of the Nb/Nb5Si3/Cr2Nb phase volume fraction combinations was conducted. The results showed that Nb-Si-Cr tary samples with the relative density larger than 98.42％ were obtained by SPS processing, and the samples all consisted of Nb, Nb5Si3 and Cr2Nb phases that were distributed homogeneously. The fracture toughness KQ of the Nb/Nb5Si3/Cr2Nb microstructure, which was dominated by the Nb phase, naturally increased with the Nb fraction. As expected, the room-temperature Vickers hardness and the high-temperature strength of the bulk alloys increased monotonically with the increasing of the stiffening Nb5Si3 fraction. Interestingly, the binary Cr2Nb phase played a positive role in the high temperature strength and oxidation resistance. Finally, the fracture modes of the typical Nb/Nb5Si3/Cr2Nb microstructures under bending and compression conditions at room and high temperatures as well as the oxidation mechanism are described and discussed.