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瞬时受体电位香草酸亚型1(transient receptor potential vanilloid 1,TRPV1)通道是一种非选择性阳离子通道,可以被辣椒素、高温等多种刺激因素激活。近年来多项研究表明,TRPV1通道在心血管疾病中发挥重要作用。该文旨在综述现阶段TRPV1通道在调节血管平滑肌细胞(vascular smooth muscle cell,VSMC)功能和降低高血压等相关疾病作用的研究进展。
Transient receptor potential vanilloid 1 (TRPV1) channel is a non-selective cation channel, which can be activated by many stimulating factors such as capsaicin and hyperthermia. In recent years, a number of studies have shown that TRPV1 channel plays an important role in cardiovascular disease. The aim of this article is to review the current research progress on the role of TRPV1 in the regulation of vascular smooth muscle cell (VSMC) function and the reduction of hypertension-related diseases.