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Hepcidin是调节机体铁稳态的一类抗菌多肽。在炎症和感染时,炎性细胞因子可直接刺激肝脏表达合成hepcidin,通过hepcidin负性铁调节作用,抑制单核-巨噬细胞系统铁释放和肠道铁吸收,最终导致低铁血症,诱发贫血。随着对hepcidin的不断研究,针对hepcidin信号转导途径的特异性的靶向治疗,从分子角度切断铁的不足,纠正低铁血症将给铁代谢紊乱相关疾病如慢性病贫血的治疗带来新的希望。
Hepcidin is a class of antimicrobial peptides that regulate the body’s iron homeostasis. In inflammation and infection, inflammatory cytokines directly stimulate the hepatic expression of synthetic hepcidin, which inhibits iron release from the monocyte-macrophage system and intestinal iron absorption through hepcidin negative iron regulation, eventually leading to hypoferremia and anemia . With the continuous research of hepcidin, targeted targeted therapy of hepcidin signaling pathway, molecularly cut off the deficiencies of iron and correct hypoglycemia will bring new to the treatment of iron metabolism disorders related diseases such as chronic diseases and anemia hope.