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无功能性垂体腺瘤(NFPA)是垂体腺瘤的一种常见类型，缺乏激素过度表达的临床或生化特征，易呈侵袭性大腺瘤并压迫周围组织，给患者带来巨大痛苦。目前关于NFPA发病机制尚不明确，缺乏有效的内科治疗药物，经蝶手术虽作为NFPA一线治疗方案，但很难取得治愈效果。研究发现，环氧合酶-2(COX-2)的异常表达影响肿瘤生存及进展。近来的研究已在垂体肿瘤中检测出有COX-2的表达，且在NFPA中COX-2的表达更强，提示COX-2可能参与了NFPA的发生发展过程。本文就NFPA的发病机制与COX-2致瘤作用进行综述，以期为临床治疗NFPA提供新思路。“,”Non-functioning pituitary adenoma (NFPA), lack of the clinical and biochemical characteristics of hormone overexpression, is a common type of pituitary adenoma. It could bring enormous suffering to the patients on account of the tendentiousness of being invasive macroadenoma and oppressing surrounding tissue. At present, the pathogenesis of NFPA is still unclear, thus there is no effective medical management for the disease. Although transsphenoidal surgery is the first-line treatment for NFPA, it is very difficult to achieve a cure effect. It has been found that the abnormal expression of cyclooxygenase-2 (COX-2) affects the survival and progression of cancer. Recent studies have detected the expression of COX-2 in pituitary tumors, and the expression of COX-2 in NFPA is stronger, suggesting that COX-2 may be involved in the occurrence and development of NFPA. This article reviews the pathogenesis of NFPA and the tumorigenicity of COX-2, and provides new ideas for clinical drug treatment of NFPA.