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在心肌缺血再灌注犬模型上，观察内源性白三烯（LTC4）的动态变化，结果显示，再灌注后冠状窦血LTC4浓度在心肌缺血后升高的基础上又明显升高，3小时升至峰值后下降。早灌注组LTC4与再灌注心律失常呈正相关。早灌注组心梗面积小于晚灌注组。同时还发现白细胞可能是LTC4主要来源之一，冠状窦血白细胞在心肌缺血－再灌注后释放LTC4的能力下降，下降百分率与心梗面积呈正相关。提示LTC4可能与心肌缺血－再灌注损伤机制有关。
The dynamic changes of endogenous leukotriene (LTC4) were observed in myocardial ischemia-reperfusion model. The results showed that the concentration of LTC4 in coronary sinus blood was significantly increased after myocardial ischemia, 3 hours after the peak rose to decline. The early perfusion group LTC4 and reperfusion arrhythmia was positively correlated. Early myocardial infarction area was smaller than the late perfusion group. Also found that leukocytes may be one of the main sources of LTC4, coronary sinus white blood cells in myocardial ischemia - reperfusion after release of LTC4 capacity decreased, the percentage decline was positively correlated with myocardial infarction area. These results suggest that LTC4 may be involved in the mechanism of myocardial ischemia-reperfusion injury.