论文部分内容阅读
目的:研究银翘散对流感病毒FM1感染小鼠的保护作用及作用机制。方法:将实验小鼠分为空白对照组、模型组、病毒唑组及银翘散大、中、小剂量组,分别观察实验小鼠行为状态、死亡率、肺指数及肺指数抑制百分率。结果:银翘散各剂量组有明显改善流感病毒FM1感染小鼠行为状态的作用;银翘散中、小剂量组与模型组比较,死亡率显著降低,表明银翘散对流感病毒FM1感染小鼠具有保护作用;银翘散大、中剂量组显著降低流感病毒FM1感染小鼠模型的肺指数,说明银翘散能显著抑制病毒在体内增殖,减轻肺部炎性病变。结论:银翘散中、小剂量组对流感病毒FM1感染小鼠具有保护作用,其作用机制可能与银翘散能显著抑制病毒在体内的增殖、减轻肺部炎性病变有关。
Objective: To study the protective effect and mechanism of Yinqiao powder on influenza virus FM1 infected mice. METHODS: The experimental mice were divided into blank control group, model group, Ribavirin group, and Yinqiaosan large, medium and low dose groups. The percentage of inhibition of behavioral state, mortality, lung index, and lung index of the experimental mice was observed. RESULTS: Each group of Yinqiao Powder significantly improved the behavior of the influenza virus FM1 infected mice. Compared with the model group, the mortality rate of the Yinqiao Powder group was significantly lower than that of the model group, indicating that Yinqiao Powder had little effect on the influenza virus FM1 infection. Rats have a protective effect; Yinqiaosan large and medium dose group significantly reduced the lung index of the influenza virus FM1 infected mouse model, indicating that Yinqiaosan can significantly inhibit the proliferation of the virus in the body and reduce the inflammatory lesions of the lung. Conclusion: The middle and low doses of Yinqiao Powder have protective effects on influenza virus FM1 infected mice. The mechanism may be related to Yinqiao Powder can significantly inhibit the proliferation of the virus in the body and reduce the inflammatory lesions in the lung.