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目的探讨复发性早期流产的治疗方法。方法复发性早期流产患者90例,随机分为A,B,C 3组各30例,A组给予黄体酮+绒毛膜促性腺激素(human chorionic gonadotrophin,HCG),B组给予黄体酮胶囊,C组给予地屈孕酮,分别于妊娠6,8,11周检测3组血清孕酮及人血清HCGβ亚型(β-HCG)水平,评估用药效果。结果相同孕周时,A组血清孕酮及β-HCG水平均较B,C组高(P<0.05),B组孕酮水平较C组高(P<0.05),但B,C组β-HCG水平差异无统计学意义(P>0.05);A,B,C组保胎成功率分别为96.7%,90.0%,86.7%,组间比较差异有统计学意义(P<0.05)。结论绒毛膜促性腺激素联合黄体酮应用可提高复发性早期流产的保胎成功率,疗效优于单用黄体酮或地屈孕酮,而单纯应用黄体酮较地屈孕酮保胎效果好。
Objective To explore the treatment of recurrent early abortion. Methods Ninety patients with recurrent spontaneous abortion were randomly divided into three groups: A, B and C, 30 cases in each group, group A received progesterone plus human chorionic gonadotrophin (HCG), group B received progesterone capsules, C Group given to bend progesterone, respectively, at 6, 8, 11 weeks of pregnancy serum progesterone and serum HCGβ subtype (β-HCG) levels were measured three groups to assess the drug effect. Results In the same gestational weeks, serum progesterone and β-HCG levels in group A were significantly higher than those in group B and C (P <0.05), and those in group B were higher than those in group C (P <0.05) (P> 0.05). The success rates of miscarriage in groups A, B and C were 96.7%, 90.0% and 86.7%, respectively. The difference between the two groups was statistically significant (P <0.05). Conclusions The application of chorionic gonadotrophin combined with progesterone can improve the success rate of miscarriage in recurrent early abortion, and the curative effect is better than that of progesterone alone or progesterone alone.