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通过检索Pub Med、Cochrane Controlled Trial Register、OVID、万方、中国生物医学文献数据库和CNKI数据库,收集抗菌药物治疗细菌性阴道炎(BV)预防早产的临床随机对照试验的13篇文献,筛选、评价文献并提取数据进行Meta分析。抗菌药物治疗BV并不能降低早产发生率(OR=0.89,95%CI=[0.68,1.17],P=0.40);22孕周前使用抗菌药物治疗BV有助于降低早产发生率(OR=0.76,CI=[0.59,0.98],P=0.03)。在有充足的证据之前,不推荐使用抗菌药物治疗BV预防早产;22孕周前使用抗菌药物治疗BV有助于降低早产率,但该结论还有待研究来证实。
Thirteen literatures of clinical randomized controlled trials of antimicrobial treatment of bacterial vaginosis (BV) in the prevention of preterm birth were collected by searching Pub Med, Cochrane Controlled Trial Register, OVID, Wanfang, China Biomedical Literature Database and CNKI database. Literature and data extraction Meta-analysis. Antibacterial treatment of BV did not reduce the incidence of preterm delivery (OR = 0.89, 95% CI = [0.68,1.17], P = 0.40); treatment of BV with antibacterials before 22 weeks gestation helped to reduce the incidence of preterm delivery (OR = 0.76 , CI = [0.59, 0.98], P = 0.03). Antibiotics are not recommended for prophylaxis of preterm birth until sufficient evidence is available; treatment of BV with antibacterials before the 22th week of gestation may help reduce preterm birth rates, but the conclusion remains to be seen.