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目的研究中心静脉导管置管在大量恶性胸腔积液治疗中的疗效和安全性。方法回顾性分析178例大量恶性胸腔积液患者的病历资料。其中60例采用中心静脉导管置管闭式引流加药物灌注治疗(Ⅰ组),60例采用传统置管闭式引流加药物灌注治疗(Ⅱ组),58例采用传统抽液加药物灌注治疗(Ⅲ组)。结果Ⅰ组完全缓解36例,部分缓解20例,无效4例,Ⅱ组完全缓解28例,部分缓解24例,无效8例,Ⅲ组完全缓解10例,部分缓解12例,无效36例。结论中心静脉导管置管闭式引流加药物灌注治疗具有疗效好、不良反应少和患者易于接受等优点,值得临床推广应用。
Objective To study the efficacy and safety of central venous catheterization in the treatment of massive malignant pleural effusion. Methods A retrospective analysis of 178 cases of malignant pleural effusion in patients with medical records. Sixty cases were treated with catheterization of central venous catheter and drug infusion (group Ⅰ). Sixty patients were treated with traditional catheterization and closed perfusion and drug infusion (group Ⅱ). Fifty-eight patients were treated by traditional fluid-withdrawing plus drug infusion Group Ⅲ). Results In group Ⅰ, 36 cases were completely relieved, 20 cases partially relieved and 4 ineffective. The complete remission was relieved in 28 cases in group Ⅱ, 24 cases were partially relieved, 8 cases were ineffective, 10 cases were completely relieved in group Ⅲ, 12 cases were partially relieved and 36 cases were ineffective. Conclusion Central venous catheters with closed drainage and drug infusion therapy has the advantages of good curative effect, less adverse reactions and easy acceptance of patients, which is worthy of clinical application.