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探讨过度换气治疗颅高压过程中经颅多普勒超声（ＴＣＤ）监测的价值。方法３０只家兔随机分为３组，每组１０只，Ａ组，正常对照组。Ｂ组和Ｃ组采用硬脑膜外腔置气囊法制成不同程度的颅高压模型，过度换气３０分钟观察实验前后ＭＣＡ的平均脑血流速度（ＴＡＭ）和颅内压（ＩＣＰ）变化。结果：（１）随着ＩＣＰ增加，ＴＡＭ下降，ＩＣＰ和ＴＡＭ呈负相关；（２）过度换气致颅高压组家兔脑血流速度下降的同时ＩＣＰ也降低，ＩＣＰ降低的程度取决于脑血管的ＣＯ２反应性，当ＩＣＰ显著增高至舒张期末血流信号丧失时，脑血管的ＣＯ２反应性近于丧失，过度换气无降颅压作用。结论：过度换气过程中应用ＴＣＤ监测可为脑血流灌注情况和降颅压措施的选择提供信息
To investigate the value of transcranial Doppler ultrasound (TCD) monitoring during hyperventilation in the treatment of intracranial hypertension. Methods Thirty rabbits were randomly divided into 3 groups, 10 in each group, group A, normal control group. In group B and group C, epidural balloon catheter was used to make different models of intracranial hypertension. The mean cerebral blood flow velocity (TAM) and intracranial pressure (ICP) changes of MCA before and after the experiment were observed by hyperventilation for 30 minutes. Results: (1) TMA decreased with the increase of ICP, but negatively correlated with ICP and TAM; (2) ICP decreased with decrease of cerebral blood flow in hypercapnic group; the degree of ICP decreased was dependent on the brain Vascular CO2 reactivity, when ICP was significantly increased to the end of diastolic blood flow signal loss, the cerebrovascular CO2 reactivity almost lost, hyperventilation without intracranial pressure. Conclusions: The use of TCD monitoring during hyperventilation provides information on the choice of measures of cerebral perfusion and intracranial pressure