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目的研究下咽癌中环氧化酶-2(COX-2)的表达及其与肿瘤临床病理参数的关系。方法应用免疫组化SP法检测40例下咽癌组织及15例癌旁下咽黏膜组织(对照组)中COX-2的表达,并分析癌组织中COX-2的表达强度与肿瘤对应的各项病理参数的关系。结果下咽癌组织中COX-2的阳性表达率(67·5%)明显高于癌旁下咽黏膜组织中COX-2的阳性表达率(20·0%),COX-2的阳性表达与下咽癌的临床分期及淋巴结转移有显著相关性(均P<0·01)。结论COX-2在下咽癌组织中表达增高,并与肿瘤的恶性度相关,表明COX-2可能在下咽癌的发生发展中起重要的作用。
Objective To study the expression of cyclooxygenase-2 (COX-2) in hypopharyngeal carcinoma and its relationship with clinicopathological parameters. Methods The expression of COX-2 in 40 cases of hypopharyngeal carcinoma and 15 cases of para-cancerous mucosa (control group) was detected by immunohistochemical SP method. The expression of COX-2 in cancer tissues was analyzed with the corresponding The relationship between the pathological parameters. Results The positive rate of COX-2 expression in hypopharyngeal carcinoma (67.5%) was significantly higher than that in adjacent cancerous oropharyngeal mucosa (20.0%). The positive expression of COX-2 and Hypopharyngeal carcinoma clinical stage and lymph node metastasis were significantly correlated (P <0.01). Conclusions COX-2 is highly expressed in hypopharyngeal carcinoma and correlates with the malignancy of the tumor, indicating that COX-2 may play an important role in the pathogenesis of hypopharyngeal carcinoma.