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胰岛素促泌剂是目前治疗2型糖尿病的一类主要口服降糖药,是非肥胖及部分肥胖2型糖尿病的一线治疗药物。近年来研究发现,2型糖尿病患者胰岛β细胞凋亡明显增加,二者之间的关系及2型糖尿病胰岛β细胞凋亡的机制逐渐成为人们关注的热点。由于它的治疗作用与胰岛β细胞的功能状态密切相关,本文就各种胰岛素促泌剂对胰岛β细胞功能的影响予以综述,为2型糖尿病的合理用药提供新思路。
Insulin secretagogues is a class of major oral hypoglycemic agents currently used in the treatment of type 2 diabetes. It is a first-line treatment for non-obese and partially obese type 2 diabetes. In recent years, the study found that type 2 diabetes patients with pancreatic β-cell apoptosis increased significantly, the relationship between the two and type 2 diabetes, pancreatic β-cell apoptosis mechanism has gradually become a hot topic. Because its therapeutic effect is closely related to the functional status of pancreatic β-cells, this review summarizes the effects of various insulin secretagogues on pancreatic β-cell function and provides new ideas for rational drug use in type 2 diabetes.