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1.前言:理想的动物模型应该是免疫性无改变的动物,能使麻风临床类型的整个谱系、反应性意外和伴有畸形的周围神经炎,象在人身上一样,全部显现出来。但目前还没有一种能满足这种需要。鉴于这些问题的重要性,本文将着重讨论那些有可能作为多菌型(即BL到LL型)麻风模型的动物。2.历史背景1873年2月28日,汉森在他的简陋的小实验室里,从病人Gil的鼻翼上切取一些“大结节”进行观察,于是发现了一些棕色的杆状小体(汉森1874.1880)。尽管还没有其它的人类慢性病的可传染的病原被报告过,并且与那时所流行的麻风是遗传性疾病的观点相反,汉森还是根据在挪威进行的流行病学观察相信:麻风是一种传染病,并勇敢地宣告这些杆状体就是其
1. INTRODUCTION: The ideal animal model should be an animal with no change in immunity, allowing the entire spectrum of leprosy clinical types, reactive accidents and peripheral neuritis associated with deformities to appear as if in humans. However, at present there is no one that can meet this need. In view of the importance of these issues, this article will focus on those animals that are likely to be leprosy models of multi-fungal (ie BL to LL). 2. History Background On February 28, 1873, in his crude little laboratory, Hansen observed some of the “nodules” from his patient’s nose, and found some brown rods Hansen 1874.1880). Although no other communicable pathogen of human chronic disease has been reported, and contrary to the prevailing prevalence of leprosy being a hereditary disease at the time, Hansen believes, based on epidemiological observations in Norway, that leprosy is a Infectious disease, and courageously declare these rods is its