【摘 要】
：
Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell nucleus.However,their delivery into the nucleus is often limited.Nuclear delivery could be enhanced with a rationally designed cargo-delivery scaff
【机 构】
：
State Key Laboratory for Chemo/Bio-Sensing and Chemometrics,College of Chemistry and Chemical Engine
论文部分内容阅读
Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell nucleus.However,their delivery into the nucleus is often limited.Nuclear delivery could be enhanced with a rationally designed cargo-delivery scaffold,but this approach has rarely been successfully implemented.Herein,a stable,biocompatible molecular capsule that encapsulates and delivers camptothecin,a DNA topoisomerase I inhibitor,into the nucleus of living cells was reported.Nuclear delivery is facilitated by the ultra-small diameter,zero net charge,and hydrophobicity of the capsule.The encapsulated drug complex displays superior toxicity towards multiple cancer cells over the free drug,the Food and Drug Administration (FDA)approved drugs,as well as conventionally reported drug vectors.Additionally,it inhibits liver cancer tumor growth in a xenograft mouse model.Modification of the properties of such molecular capsules may make it possible to design therapeutic strategies that target specific cell organelles.
其他文献
Bifunctional electrocatalysts with high activity toward both oxygen reduction and evolution reaction are highly desirable for rechargeable Zn-air batteries.Herein,a kind of carbon nanotube (CNT) supported single-site Fe-N-C catalyst was fabricated via pyr
Enhancing electrocatalytic water splitting performance by modulating the intrinsic electronic structure is of great importance.Here,porous bimetallic oxide and chalcogenide nanosheets grown on carbon paper denoted as NiCo2X4/CP (X =O,S,and Se) are prepare
广西合浦儒艮国家级自然保护区位于北部湾东北部,目前以保护鲸豚类动物为主,为研究鲸豚类的食物资源——鱼类资源多样性情况,2018—2019年秋冬季,对儒艮保护区及其邻近海域开展鱼类资源底拖网调查.结果表明,该海域共捕获鱼类124种,隶属14目44科92属.相对重要性指数IRI表明2018年10月线纹鳗鲶(Plotosus lineatus)为优势种,2019年1月铅点东方鲀(Takifugu alboplumbeus)和犬牙缰鰕虎鱼(Amoya caninus)为优势种,2019年10月条马鲾(Equuli
Two-dimensional materials have been demonstrated as promising toolboxes for optoelectronics.Transition metal carbides and nitrides (MXenes),members of an emerging family of two-dimensional materials,have drawn extensive attention in optoelectronics owing
Photoelectrochemical oxygen reduction reaction (ORR) toward H2O2 is highly desirable because only sunlight,O2 and water are required in the process.However,the corresponding studies are still at its infancy because of the lack of suitable photocathodes,es
Despite acknowledgment of structural reconstruction of materials following oxygen evolution reaction (OER) reaction,the role of support during the reconstruction process has been ignored.Given this,we directly in situ transform the residual iron present i
Water oxidation,an essential step in photosynthesis,has attracted intense research attention.Understanding the reaction pathways at the electrocatalyst/water interface is of great importance for the development of water oxidation catalysts.How the water i
Despite the extensive application of porous nanostructures as oxygen electrocatalysts,it is challenging to synthesize single-metal state materials with porous structures,especially the ultrasmall ones due to the uniform diffusion of the same metal.Herein,
Designing earth-abundant electrocatalysts with high performance towards water oxidation is highly decisive for the sustainable energy technologies.This study develops a facile natural corrosion approach to fabricate nickel-iron hydroxides for water oxidat
Lithium-sulfur (Li-S) battery has attracted intensive attention in the realm of energy storage owing to its high theoretical capacity and energy density.However,the shuttle effect of soluble lithium polysulfides (LiPSs) between electrodes results in rapid