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目的研究在高骨代谢状态时不同加力时间对大鼠微种植体支抗的稳定性。方法健康Wistar雌性大鼠40只,分为A(高骨代谢即刻加力)组、B(高骨代谢2周加力)组、C(正常即刻加力)组、D(正常2周加力)组。A和B组建立高骨代谢模型,B和D组大鼠左侧胫骨植入直径1.5mm的钛合金钉2枚,2周后A和C组植入同样钛合金钉,然后各组同时负载100g力,30d后处死动物。测量钛合金钉间距;制作硬组织切片,甲苯胺蓝染色,观察钛合金钉种植体与软硬组织愈合情况并计算骨结合率。结果 4组大鼠钛合金钉种植体无脱落,个别有倾斜;其移动距离、BIC比较,差异有统计学意义(F=113.959和334.55,P均<0.01;F=2.326和2.40,P>0.05),A和B组钛合金钉微种植体移动距离大于C和D组,骨结合率A和B组高于C和D组。结论高骨代谢情况下钛合金钉微种植体即刻、延期加力是可行的,不同加力时间对微种植体稳定性影响较小,但在临床中注意微种植体植入时的安全距离。
Objective To study the stability of rat micro-implant anchorage with different post-application time in the metabolic state of high bone. Methods Forty healthy Wistar female rats were divided into two groups: A group (BMS group), B group (BMS group), C (normal group) and D group (normal group). Groups A and B established a model of high bone metabolism. Groups B and D were implanted with two titanium alloy pins 1.5 mm in diameter on the left tibia. Groups A and C were implanted with the same titanium alloy nail after two weeks, and each group was simultaneously loaded 100g force, 30d after the animals were sacrificed. Titanium alloy nail spacing was measured; hard tissue sections were made, toluidine blue staining was observed, the healing of titanium alloy nail implants and hard and soft tissues were observed, and the rate of bone union was calculated. Results The titanium alloy nail implants of the four groups had no shedding and were individually inclined. The moving distance and BIC were significantly different (F = 113.959 and 334.55, P <0.01; F = 2.326 and 2.40, P> 0.05 ). The moving distance of titanium alloy nail implants in groups A and B was greater than those in groups C and D, and the rates of bone union in groups A and B were higher than those in groups C and D. Conclusions The immediate and delayed application of titanium alloy micro-implants under high bone metabolism is feasible. The effect of different post-application time on the stability of micro-implants is small. However, the safety distance of micro-implants should be noticed in clinic.