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目的探究二线不同化疗方案对小细胞肺癌的治疗效果。方法选取2011年2月—2014年4月的305例确诊的小细胞肺癌(small cell lung cancer,SCLC)患者,其中有147例患者在一线治疗无效后进行二线化疗,对治疗效果予以对比。结果甲组与乙1组患者的客观缓解率、无进展生存时间、总生存时间之间的对比(P>0.05);乙2组、丙组、丁组二线客观缓解率、疾病控制率、无进展生存时间、总生存时间对比(P>0.05);丁组中位总生存时间好于乙2组与丙组(P<0.05);乙2组与丙组中位总生存时间的对比(P>0.05)。结论小细胞肺癌患者采用二线化疗效果显著,不同二线化疗方案使患者的近期缓解与无进展生存靠近;耐药/难治型患者二线化疗利用含TPT方案能够为患者带来较好效果。
Objective To investigate the therapeutic effect of second-line chemotherapy on small cell lung cancer. Methods A total of 305 patients with small cell lung cancer (SCLC) diagnosed from February 2011 to April 2014 were selected. Among them, 147 patients were treated with second-line chemotherapy after the first-line treatment was ineffective, and the treatment effect was compared. Results The objective response rate, progression-free survival time and overall survival time in group A and group B were significantly lower than those in group B (P> 0.05). The second-line objective response rates, disease control rates, (P> 0.05). The median overall survival time of group D was better than that of group B and group C (P <0.05). The median overall survival time of group B and group C was significantly higher than that of group B > 0.05). Conclusions Second-line chemotherapy is effective in patients with small-cell lung cancer. Different second-line chemotherapy regimens make the recent remission and progression-free survival close. Second-line chemotherapy with TPT in drug-resistant / refractory patients can bring better results for patients.