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目的:探讨TLR4与脓毒症性急性肾损伤的相关性,科学提出脓毒症患者预后情况。方法:采用回顾性方法分析,选取我院自2010年1月-2013年1月以来收治的60例脓毒症患儿,选择同期的60例健康儿童最为对照组,进行TLR4(Asp299Gly、Thr399Ile)基因多态性检测,通过计算多态位点在两组中的分布频率,按照Hardy-Weinberg遗传平衡定律进行检验,从而比较不同组别之间的各个基因频率是否有显著的差异。结果:60例脓毒症患儿中发现TLR4出现突变基因,而60例健康儿童中并没有发现突变基因,具有差异统计学意义(P>0.05)。结论:TLR4(Asp299Gly、Thr399Ile)基因多态性与脓毒症有密切的关系,不同个体对脓毒症的易感性也存在不同的个体差异,在临床上表现以及预后可能都有所不同,需要进行进一步的研究。
Objective: To investigate the relationship between TLR4 and septic acute kidney injury and to provide a scientific prognosis of patients with sepsis. Methods: A retrospective analysis was conducted in 60 children with sepsis treated in our hospital from January 2010 to January 2013. 60 healthy children in the same period were selected as control group, and TLR4 (Asp299Gly, Thr399Ile) Genetic polymorphisms were detected by calculating the distribution frequency of polymorphic loci in the two groups according to the Hardy-Weinberg law of genetic balance to compare whether there is a significant difference in each gene frequency between different groups. Results: The mutation gene of TLR4 was found in 60 children with sepsis, but no mutation was found in 60 healthy children. There was a statistically significant difference (P> 0.05). Conclusion: The genetic polymorphisms of TLR4 (Asp299Gly, Thr399Ile) are closely related to sepsis. Different individuals have different individual differences in the susceptibility to sepsis. The clinical manifestations and prognosis may be different and need to be different For further research.