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碱性磷酸酶(ALP)广泛分布于细菌和动植物界,在人体以肝、骨、肾、胎盘和小肠的活性最高,肺和嗜中性白细胞也有活性。ALP主要分布在细胞的质膜,在一些疾病时可释入血中,使血清ALP增高。正常组织表达的ALP同工酶ALP是一种糖蛋白。根据酶学和免疫学性质可将正常组织表达的ALP同工酶分为三类:①肝型ALP,包括肝、骨、肾、肺等的ALP.许多酶学性质是相同的,如对热失活敏感,易受L-同型精氨酸(L-HArg)和左
Alkaline phosphatase (ALP) is widely distributed in the bacteria and animal and plant kingdom. It has the highest activity in the liver, bone, kidney, placenta and small intestine and also in lung and neutrophils. ALP is mainly distributed in the cell’s plasma membrane, in some diseases can be released into the blood, so that serum ALP increased. ALP isoenzyme ALP, expressed in normal tissues, is a glycoprotein. ALP isoenzymes expressed in normal tissues can be divided into three groups based on their enzymatic and immunological properties: 肝 ALP of the liver type, including ALP of the liver, bone, kidney, lung, etc. Many of the enzymatic properties are the same, Sensitive to deactivation, susceptible to L-homocysteine (L-HArg) and left