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白藜芦醇作为一种来自葡萄和其他植物的天然多酚化合物。广泛的药理活性,抗氧化,清除自由基,保护血管内皮细胞,抑制炎症细胞活化和炎症介质的释放以及阻止巨噬细胞和平滑肌的增殖,从而发挥抗动脉粥样硬化作用。并具有抑制细胞周期、促进凋亡的抗肿瘤和类雌激素等作用。本文结合近年来白藜芦醇在抗炎作用方面的研究,探讨其在动脉粥样硬化过程中的抗炎作用机制。
Resveratrol is a natural polyphenol compound from grapes and other plants. Extensive pharmacological activity, anti-oxidation, scavenging of free radicals, protection of vascular endothelial cells, inhibition of inflammatory cell activation and release of inflammatory mediators, and prevention of macrophage and smooth muscle proliferation to exert antiatherogenic effects. It also has anti-tumor and estrogen-like effects that inhibit cell cycle and promote apoptosis. In this paper, the anti-inflammatory effect of resveratrol in recent years has been studied to explore its anti-inflammatory mechanism in the process of atherosclerosis.