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目的:探讨聚桂醇局部注射治疗婴幼儿颌面部血管瘤的效果。方法:将100例颌面部血管瘤患儿随机分为鱼肝油酸钠加地塞米松组(A组,n=25)、平阳霉素加地塞米松组(B组,n=25)、聚桂醇组(C组,n=25)和聚桂醇加地塞米松组(D组,n=25),比较各组疗效及不良反应。结果:随访时间2-13个月,A组治愈10例、显效12例、有效1例,2例未能坚持治疗;B组治愈11例、显效10例、有效1例,3例未能坚持治疗;C组治愈18例、显效3例、有效3例,1例未能坚持治疗;D组治愈19例、显效3例、有效2例,1例未能坚持治疗。C、D组的治愈率明显高于A、B组(P<0.05),且C、D组硬化注射后腹部不适和低热的不良反应明显少于A、B组(P<0.05)。结论 :以聚桂醇为主的硬化剂局部注射治疗婴幼儿颌面部血管瘤的疗效好,副作用少。
Objective: To investigate the effect of local injection of La Guinaol on infantile maxillofacial hemangiomas. Methods: One hundred children with maxillofacial hemangiomas were randomly divided into four groups: sodium codanserinate plus dexamethasone group (n = 25), bleomycin plus dexamethasone group (n = 25) Group C (n = 25) and dexamethasone plus dexamethasone group (group D, n = 25). The curative effect and side effect of each group were compared. Results: The follow-up time ranged from 2 to 13 months. A group was cured in 10 cases, markedly effective in 12 cases, effective in 1 case and 2 cases failed to adhere to treatment. In group B, 11 cases were cured, 10 cases markedly effective, 1 effective and 3 cases failed to adhere C group was cured in 18 cases, markedly effective in 3 cases, effective in 3 cases, 1 case failed to adhere to treatment; D group cured 19 cases, 3 cases markedly effective in 2 cases, 1 case failed to adhere to the treatment. The cure rates in C and D groups were significantly higher than those in A and B groups (P <0.05). The adverse reactions of abdominal discomfort and hypothermia in C and D groups were significantly less than those in A and B groups (P <0.05). Conclusion: Local injection of hardener mainly based on lauryl alcohol has good curative effect and less side effects on maxillofacial hemangiomas in infants.