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对 2 9例重症肌无力 (MG )患者同时进行了HLA DPB1分型 (聚合酶链反应 限制性片段长度多态性多酶共同消化法 )及AchRAb、Pre SmAb (ELISA )测定 ,籍以探讨MG患者HLA DPB1与AchRAb及Pre SmAb的相关关系。结果表明AchRAb阳性患者与DPB1 0 5 0 1、 2 70 1及 3 60 1密切相关 ,而AchRAb阴性患者与DPB1 3 60 1及 0 10 1相关 ;Pre SmAb阳性患者与DPB1 0 5 0 1、 3 60 1、 2 70 1相关外 ,还与 0 10 1相关 ,而Pre SmAb阴性患者与这些等位基因无明显相关关系。上述结果提示HLA DPB1与MG的AchRAb和Pre SmAb关联
A total of 29 patients with myasthenia gravis (MG) underwent simultaneous HLA DPB1 typing (polymerase chain reaction restriction fragment length polymorphism (PCR) digestion) and AchRAb, PreSmAb (ELISA) The correlation between HLA-DPB1 and AchRAb and Pre-SmAb in patients. The results showed that AchRAb-positive patients were closely related to DPB15011, 2701 and3601, whereas AchRAb-negative patients were associated with DPB1301 and 0101; Pre-SmAb-positive patients were associated with DPB15011, 1, 2 70 1, but also related to 0 10 1, while there was no significant correlation between Pre SmAb-negative patients and these alleles. The above results suggest that HLA DPB1 associates with AchRAb and PreSmAb of MG