铜绿假单胞菌是一种革兰阴性的条件致病菌,是院内感染常见的病原体之一.铜绿假单胞菌具有天然或者获得性的多重耐药性,采用疫苗防治其感染是当前的研究热点.铜绿假单胞菌的外膜蛋白Ⅰ是一种脂蛋白,不但具有良好的免疫原性,而且在不同血清型之间具有交叉保护作用.本文拟就外膜蛋白Ⅰ的特性、重组抗原疫苗、DNA疫苗和重组沙门氏菌疫苗等方面的研究现状进行综述.“,”Pseudomonas aeruginosa is a gram-negative,opportunistic pathogen that causes nosocomial infections.P.aeruginosa is a multidrug-resistant bacterium,and research has focused on using vaccines to control it.Outer membrane protein Ⅰ (OprI) is a lipoprotein that has excellent immunogenicity and cross-protective immunity among all known P.aeruginosa serotypes.This review summarizes the status of research on the characteristics of OprI,recombinant antigen vaccines,DNA vaccines,and recombinant vector vaccines.