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目的探讨肺功能深吸气量(IC)的测定在慢性阻塞性肺病(COPD)患者中的临床应用价值。方法对28例中重度稳定期COPD患者分别在吸入支气管扩张剂前后进行常规肺功能检测和6分钟步行试验(6MWT)后肺功能检测,以Borg指数进行呼吸困难的分级。结果吸入沙丁胺醇后,IC增加超过15﹪的占67.9﹪,第1秒用力呼气容积(FEV1)增加超过15﹪的占17.9﹪。运动后FEV1的下降程度均不及IC下降明显,两者差异有高度统计学意义(P﹤0.01)。运动后,Borg指数的变化与IC的变化成显著负相关(P<0.01)。吸入沙丁胺醇后,6MWT和Borg呼吸困难评分均有显著改善,IC的增加(△IC)与△6MWT及△Borg之间存在显著相关性。结论对COPD患者,评价支气管扩张剂的疗效时,IC比FEV1更敏感,并能较准确地反映患者呼吸困难的严重程度。
Objective To investigate the value of lung function deep inspiratory volume (IC) determination in patients with chronic obstructive pulmonary disease (COPD). Methods Twenty-eight patients with moderate-to-severe stable COPD underwent routine pulmonary function tests before and after inhalation of bronchodilators and pulmonary function tests after a 6-minute walk test (6MWT). Borg index was used to classify dyspnea. Results After inhalation of albuterol, IC increased more than 15% of 67.9%, the first second forced expiratory volume (FEV1) increased more than 15% of the 17.9%. The decrease of FEV1 after exercise was lower than that of IC, and the difference between them was highly statistically significant (P <0.01). After exercise, the change of Borg index was negatively correlated with the change of IC (P <0.01). Inhalation of salbutamol, 6MWT and Borg dyspnea scores were significantly improved, IC increased (△ IC) and △ 6MWT and △ Borg there is a significant correlation between. Conclusions ICC is more sensitive than FEV1 in assessing the efficacy of bronchodilators in patients with COPD and can more accurately reflect the severity of dyspnea in patients.