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目的 :探讨中药制剂“阻育丸”对雌性 SD大鼠的绝育效果及绝育机理。方法 :根据阴道涂片结果 ,选择动情前期一次顿服“阻育丸”3.75 g/ kg,并进行服药前后妊娠率 ,动情周期各时期 FSH、L H、E2 、P的比较及行解剖学检查。结果 :服用“阻育丸”后绝育率达 87.5 % ,妊娠的胚胎数也明显降低 ,各动情周期中 FSH显著下降 ,E2 、P未见显著性差异。病理切片卵巢组织中仅见各级发育的卵泡 ,未见排卵及黄体形成。结论 :“阻育丸”是一种方便、简单、安全、有效、价廉、无痛苦的绝育方法
OBJECTIVE: To investigate the sterility and sterility mechanism of traditional Chinese medicine “block pill” in female SD rats. Methods: According to the result of vaginal smear, we selected 3.75 g / kg of “block pills” in the early period of estrus and compared the pregnancy rate and the estrous cycle FSH, LH, E2 and P before and after taking the medicine. Results: The rate of sterilization was 87.5% after taking “blocking pills”, the number of embryos in pregnancy was also significantly decreased, the FSH in each estrous cycle was significantly decreased, and there was no significant difference in E2 and P. Pathological sections of ovarian tissue only see the development of follicles at all levels, no ovulation and luteal formation. CONCLUSIONS: “Barrier pill” is a convenient, simple, safe, effective, inexpensive and painless sterilization method