论文部分内容阅读
目的利用弥散张量成像(DTI)直方图分析,明确复发缓解型多发性硬化(RRMS)患者表现正常脑灰质(NAGM)是否存在隐匿性损伤,并研究脑灰质DTI直方图指标与扩展残疾功能状态量表(EDSS)评分的相关性。方法对24例RRMS患者和24名性别及年龄匹配的健康志愿者行常规磁共振成像(MRI)和DTI检查,分割提取NAGM后,绘制出NAGM的平均弥散率直方图并对其进行分析。结果RRMS患者NAGM的平均弥散率[(1·134±0·086)×10-3mm2/s]明显高于健康志愿者[(0·993±0·042)×10-3mm2/s,t=7·198,P<0·01],平均弥散率直方图峰位置[(0·880±0·089)×10-3mm2/s]也明显高于健康志愿者[(0·812±0·017)×10-3mm2/s,t=3·685,P=0·001],而平均弥散率直方图峰高(6·138‰±1·371‰)明显低于健康志愿者(8·889‰±1·339‰,t=7·032,P<0·01)。RRMS患者NAGM的平均弥散率直方图各指标间的相关性明显高于健康志愿者。在RRMS患者,所有NAGM的平均弥散率直方图指标与EDSS评分均无相关性。结论RRMS患者的NAGM内存在隐匿性损伤。
Objective To investigate the occult manifestations of normal gray matter (NAGM) in patients with recurrent remitting multiple sclerosis (RRMS) using diffusion tensor imaging (DTI) histogram analysis and to study the relationship between gray matter DTI histogram and extended disability status Scale (EDSS) score correlation. Methods Twenty-four patients with RRMS and 24 healthy volunteers matched for gender and age underwent routine magnetic resonance imaging (MRI) and DTI examination. NAGM was divided and extracted, and then the histogram of average diffusivity of NAGM was drawn and analyzed. Results The mean diffusivity of NAGM in RRMS patients was significantly higher than that of healthy volunteers [(1.993 ± 0.402) × 10-3mm2 / s [(1.134 ± 0.086) × 10-3mm2 / s, t = 7 · 198, P <0 · 01]. The peak position of the average diffusivity histogram [(0.880 ± 0.089) × 10-3 mm2 / s] was also significantly higher than that of healthy volunteers [(0.812 ± 0.10 017) × 10-3mm2 / s, t = 3.685, P = 0.001, while the peak mean height of the average diffusivity (6 · 138 ‰ ± 1 · 371 ‰) was significantly lower than that of healthy volunteers 889 ‰ ± 1 · 339 ‰, t = 7 · 032, P <0.01). RRMS patients NAGM average diffusivity histogram correlation between the indicators was significantly higher than healthy volunteers. In RRMS patients, there was no correlation between the mean diffusivity histogram and the EDSS score for all NAGM. Conclusions There is occult damage in the NAGM of RRMS patients.