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近年文献报道,经十二指肠Oddi括约肌成形术(transduodenalsphincteroplasty ,TS)患者远期胆管癌发生率比正常人群明显增高[1] ,但其癌变机制尚未明确。我们通过观察TS后胆汁(TSbile ,TSB)对体外培养人胆管癌细胞增殖的影响,探讨TS与胆管癌发生和发展的关系。材料与方法1 实验材
In recent years, it has been reported in the literature that the incidence of long-term cholangiocarcinoma in the patients with TS has been significantly higher than that in the normal population [1], but the mechanism of its carcinogenesis has not been clarified yet. We observed TS after bile (TSbile) on human cholangiocarcinoma cell proliferation in vitro to explore the relationship between the TS and the occurrence and development of cholangiocarcinoma. Materials and methods 1 Experimental materials