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目的研究2种新型驱避剂,8-羟基别二氢葛缕醇甲酸酯和羟基香茅醛1,2-丙二醇缩醛在新疆伊犁地区防蚊效果。方法试验人群暴露下肢,并在下肢上均匀地涂抹驱避剂,同时以国际公认的驱避剂避蚊胺(DEET)为对照药剂,观察驱避剂的有效时间及有效率。结果新型驱避剂中20%羟基香茅醛1,2-丙二醇缩醛效果最好,最短有效时间大于6 h,有效率可达100%;20%8-羟基别二氢葛缕醇甲酸酯有效时间为3~5 h,有效率37%~67%;20%避蚊胺有效时间4 h,有效率37%;10%避蚊胺最短有效时间小于3 h,有效率为0,保护效果最差。结论新型驱避剂羟基香茅醛1,2-丙二醇缩醛在20%含量时在新疆伊犁地区对蚊虫有很好的驱避效果,驱避效果明显优于20%避蚊胺,20%R1与20%避蚊胺的效果相当。2种新型驱避剂对皮肤无任何副作用,使用方便,具有实用意义。
Objective To study the anti-mosquito effect of two new repellents, 8-hydroxy-dihydro-Cellulityl formate and hydroxycitronellal-1,2-propanediol acetal in Yili, Xinjiang. Methods The test subjects were exposed to the lower extremities and applied repellent evenly to the lower extremities. An internationally recognized repellent DEET was used as a reference drug to observe the effective time and effectiveness of the repellent. Results The 20% hydroxyacetellaldehyde 1,2-propanediol acetal had the best effect in the new repellent with the shortest effective time of more than 6 h and the efficiency of up to 100%. The 20% 8-hydroxy-dihydrogesterol formate Ester effective time of 3 ~ 5 h, the effective rate of 37% to 67%; 20% DEET effective time 4 h, the effective rate of 37%; 10% DEET minimum effective time of less than 3 h, the effective rate of 0, the protection The worst effect. Conclusions The new repellent hydroxycitronellal 1,2-propanediol acetal has a good repellent effect on mosquitoes at the level of 20% in Ili, Xinjiang, and the repellent effect is better than 20% And 20% DEET effect. Two kinds of new repellent on the skin without any side effects, easy to use, has practical significance.