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Objective:To evaluate the factors influencing success rate of in vitro fertilization /embryo transfer (IVF/ET).Methods:A retrospective study of 770 consecutive cycles undergone IVF/ET or in-tracytoplasmic sperm injection (ICSI) from March 1999 to June 2001.Estradiol and pro-gesterone concentrations on the day of hCG administration were measured.Factors ef-{ecting embryo transfer on the effects of clinical pregnancy rate were evaluated.Results:The overall clinical pregnancy rate in 770 cycles was 40.8%.Take homebaby rate was 31%.No significantly differences rate were observed between groupswith different estradiol levels.If the progesterone concentration on the day of hCG ad-ministration was>6.36 nmol/L,the implantation and clinical pregnancy rate was lower(P<0.003).The lowest clinical pregnancy rate was observed when the duration of in-fertility was≥10 years.The average number of embryos transferred was 2.23±0.83.Conclusion:This study demonstrated that the most important factor on clinicalpregnancy rate was low progesterone concentration on the day of hCG administration.The other two important variables influencing success rate of IVF/ET were the durationof infertility,the number of high-grade embryos transferred.