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由于卡介苗(BCG)在肿瘤免疫治疗中逐渐开展,故其并发症报告也渐增多。常见的是局部脓肿,其他如局部淋巴结炎、结核性苔癣、骨髓炎、肝脏等器官的肉芽肿或脓肿,以及播散性卡介苗感染等亦可发生。本文报告两例卡介苗瘤灶内注射治疗黑色素瘤而致死。其中一例作了尸检。例1,右足黑色素瘤切除,一年多后大腿出现多数小的黑素性皮损,用卡介苗瘤灶内注射,每次最大剂量是600万菌,共3次。一年后因出现新瘤子,其后两个月又再次卡介苗皮内法治疗达4个月。以后切除5个结节,并对15个瘤灶行皮内、皮下注射卡介苗,注入总量是1毫升(含5×10~8菌)。注入后在一
Because of the gradual development of the BCG vaccine in tumor immunotherapy, its complications report has gradually increased. Local abscesses are common, and other granulomas or abscesses such as local lymphadenitis, tuberculous mosses, osteomyelitis, liver, and disseminated BCG infections can also occur. This article reports two cases of intravitreal injection of BCG for the treatment of melanoma and death. One case was autopsy. Case 1, the right foot melanoma resection, more than a year after the thigh appeared a lot of small melanotic skin lesions, with the injection of BCG in the tumor foci, the maximum dose each time is 6 million bacteria, a total of 3 times. One year later, due to the emergence of new tumors, the next two months again BCG treatment of intradermal therapy for up to 4 months. Later, 5 nodules were removed, and 15 tumors were injected intradermally and subcutaneously with BCG, and the total injection volume was 1 ml (containing 5×10~8 bacteria). After infusion at a