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目的:观察与比较血清CRP在正常血压高值和正常血压人群中的表达变化。方法:选取自2010年1月至2012年12月间在启东中医院体检中心240例健康体检者,分为理想血压组和血压正常高值组,检测并比较两组受试人群收缩压,舒张压,血清CRP及总胆固醇等生化指标;经两年随访分别统计高CRP组和低CRP组受试对象患高血压率。结果:正常血压高值组收缩压平均值为(132.8±2.1)mm Hg高于理想血压组收缩压平均值(110.8±3.4)mm Hg,P<0.05;正常血压高值组舒张压平均值为(82.8±3.2)mm Hg高于理想血压组收缩压平均值(72.8±4.4)mm Hg,P<0.05;正常血压高值组血清CRP为(3.8±0.3)mg/L高于理想血压血清CRP(2.4±0.2)mg/L,P<0.05;高CRP组高血压率为51.7%高于低CRP组高血压率12.5%。结论:正常血压高值者血清CRP增高,说明在血压正常高值时期已发生炎症反应,并促进高血压的发展。
Objective: To observe and compare the changes of serum CRP in people with normal blood pressure and normotension. Methods: From January 2010 to December 2012 in Qidong Hospital, physical examination 240 cases of physical examination were divided into ideal blood pressure group and high normal blood pressure group to test and compare the two groups of subjects systolic blood pressure, Diastolic blood pressure, serum CRP and total cholesterol and other biochemical indicators; two years follow-up were statistically high CRP group and low CRP group subjects suffering from hypertension. Results: The average systolic blood pressure in high normotensive group was (132.8 ± 2.1) mm Hg higher than that in ideal blood pressure group (110.8 ± 3.4) mm Hg, P <0.05; mean diastolic blood pressure in normotensive group was (82.8 ± 3.2) mm Hg was higher than that of the ideal blood pressure group (72.8 ± 4.4) mm Hg, P <0.05; the serum CRP of the normal high blood pressure group was (3.8 ± 0.3) mg / L higher than that of the ideal blood pressure serum (2.4 ± 0.2) mg / L, P <0.05; the rate of high blood pressure was 51.7% in high CRP group and 12.5% in low CRP group. CONCLUSION: Serum CRP is elevated in patients with high normotensive hypertension, indicating that inflammatory reactions have occurred during the high normotensive period and promote the development of hypertension.