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检测儿童哮喘发作期 42例、缓解期 35例及正常对照组 2 0例血清TNF -α水平。结果表明 :哮喘急性发作期TNF-α值明显增高 ,至缓解期明显下降 ;使用激素组较未用激素组下降更显著 ,接近正常对照组水平。提示TNF -α参与哮喘发病 ,并在慢性气道炎症发生、发展过程中起重要作用
The levels of serum TNF-α in 42 cases of childhood asthma attack, 35 cases of remission and 20 cases of normal control group were detected. The results showed that TNF-α in acute exacerbation of asthma increased significantly from baseline to remission, and decreased significantly in hormone-treated group compared with that in control group, which was close to normal control group. It is suggested that TNF-α is involved in the pathogenesis of asthma and plays an important role in the occurrence and development of chronic airway inflammation