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抗氧化剂硒在抗氧化损伤方面的保护作用及在糖尿病并发症中起重要作用。为了进一步获取硒的含量和糖尿病肾病之间的联系,将研究对象分为3组:微量白蛋白尿糖尿病患者组(组1);无微量白蛋白尿糖尿病患者组(组2);正常对照组(组3),测定他们血清中谷胱甘肽过氧化物酶、硒、葡萄糖、尿素、肌酐和糖化血红蛋白的含量。结果显示,对于2组糖尿病患者来说,组1诊断为糖尿病时间和血糖浓度均较组2高。对照组血清硒含量高于糖尿病组。2个糖尿病组患者的血清硒水平相当。组1谷胱甘肽过氧化物酶的浓度显著低于组2和组3。尿微量白蛋白的含量与葡萄糖的浓度呈正相关,与硒和谷胱甘肽过氧化物酶浓度呈负相关。多重回归发现血清硒或谷胱甘肽过氧化物酶的浓度与尿微量白蛋白的含量成负相关。结果表明,糖尿病患者硒和谷胱甘肽过氧化物酶的浓度降低可能提示有糖尿病肾病。
Antioxidant selenium protects against oxidative damage and plays an important role in the complication of diabetes. In order to further understand the relationship between selenium content and diabetic nephropathy, the subjects were divided into three groups: microalbuminuria group (group 1); microalbuminuria group (group 2); normal control group (Group 3), and their serum levels of glutathione peroxidase, selenium, glucose, urea, creatinine and glycated hemoglobin were measured. The results showed that for the two groups of patients with diabetes, group 1 diagnosis of diabetes and blood glucose concentrations were higher than Group 2. The serum selenium level in the control group was higher than that in the diabetic group. Serum selenium levels were comparable in 2 diabetic patients. Group 1 glutathione peroxidase concentrations were significantly lower than those of group 2 and group 3. Urine microalbumin content was positively correlated with glucose concentration, but negatively correlated with selenium and glutathione peroxidase concentrations. Multiple regression showed that serum selenium or glutathione peroxidase concentration and urine microalbumin content is negatively correlated. The results show that diabetic patients with reduced concentrations of selenium and glutathione peroxidase may suggest diabetic nephropathy.