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目的：探讨抑郁症患者与正常对照组之间P300潜伏期和波幅的差异性。方法对中国大陆发表的57篇符合本研究入组标准的文献进行M eta分析。结果抑郁症患者组的 P300潜伏期较正常对照组显著延长（W M D＝28.89，95％ C I：27.39—30.40，z＝37.54，P＜0.01），波幅较正常对照组显著降低（WMD＝－2.42，95％ CI：－2.53—－2.30，z＝41.77，P＜0.01）。结论抑郁症患者P300的潜伏期明显延长，波幅明显降低；P300可能是抑郁症患者认知功能变化的生物学指标之一。“,”Objective To explore the differences in P300 latency and amplitude between depression pa‐tients and normal controls .Methods Meta analyses of 57 literatures meeting enrollment criteria and pub‐lished in Chinese mainland were carried out .Results P300 latency prolonged more significantly (WMD=28.89 ,95% CI:27.39—30.40 , z=37.54 , P<0.01) and amplitude lowered (WMD= -2.42 ,95% CI :-2.53— -2.30 ,z=41.77 , P<0.01) in depression patients than normal controls .Conclusion P300 la‐tency prolongs obviously and amplitude lowers in depression patients ;P300 may be one of biological pa‐rameters of cognitive function changes of depression patients .