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目的 探讨肿瘤坏死因子 α(TNF α)、白细胞介素 6 (IL 6 )在 2型糖尿病发病机制及骨密度 (BMD)改变中的作用。方法 测定 40例 2型糖尿病患者和 40例健康对照者的血清TNF α、IL 6质量浓度和左侧髋关节部位 (Fem、Troch、Ward’s三角 )及正位腰椎 (L2 L4 )BMD ,及 2型糖尿病组HbA1C、C肽、甘油三酯、HDL、BMI指标。结果 (1)病例组TNF α、IL 6质量浓度显著高于对照组。 (2 )无论在病例组或对照组中 ,骨质疏松组的TNF α、IL 6质量浓度显著高于非骨质疏松组。 (3)病例组各部位BMD均低于对照组。 (4)病例组各部位BMD分别与TNF α、IL 6、年龄、绝经后时间呈负相关性 ,BMI只与L2 、L3 、Troch部位BMD呈负相关性。 (5 )病例组TNF α、IL 6分别与年龄、绝经后时间、BMI、甘油三酯呈正相关性 ,与HDL呈负相关性。结论 2型糖尿病患者TNF α、IL 6质量浓度显著高于正常对照组 ,而BMD低于正常。
Objective To investigate the role of tumor necrosis factor α (TNF α) and interleukin 6 (IL 6) in the pathogenesis of type 2 diabetes mellitus (BMD) and bone mineral density (BMD). Methods Serum levels of TNFα, IL-6 and Fem, Troch, Ward’s triangle and L2 L4 BMD in 40 patients with type 2 diabetes mellitus and 40 healthy controls were measured. Type 2 diabetes mellitus HbA1C, C peptide, triglyceride, HDL, BMI in diabetic group. Results (1) The TNFα and IL-6 levels in the case group were significantly higher than those in the control group. (2) The concentrations of TNFα and IL-6 in osteoporosis group were significantly higher than those in non-osteoporosis group in both cases and controls. (3) The BMD of each part of the case group was lower than that of the control group. (4) The BMD of each group of cases was negatively correlated with TNFα, IL 6, age and postmenopausal time, while BMI was only negatively correlated with BMD of L2, L3 and Troch. (5) TNFα and IL-6 in the case group were positively correlated with age, postmenopausal time, BMI and triglyceride, respectively, and were negatively correlated with HDL. Conclusion The levels of TNFα and IL-6 in patients with type 2 diabetes mellitus were significantly higher than those in normal controls, while the BMD was lower than normal.