Chemistry of trichosanthin Ⅶ.The chemical cleavage of the tryptophanyl peptide bond in trichosanthin

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The single tryptophan residue of trichosanthin was cleaved by the use of BNPS-skatolereaction with STIG2 peptide fregment which was obtained from the tryptic digestion of N-succinyltrichosanthin.After separation,the N-terminal sequence of tryptophanyl C-side peptide was deter-mined by use of manual DABITC-PITC double coupling sequencing method as follows:-Leu-Ala-Leu-Ser-Lys-Gln-Ile-Gln-Ile-Ala-. The single tryptophan residue of trichosanthin was cleaved by the use of BNPS-skatole reaction with STIG2 peptide fregment which was obtained from the tryptic digestion of N-succinyltrichosanthin. After the separation, the N-terminal sequence of tryptophanyl C-side peptide was deter- mined by use of manual DABITC-PITC double coupling sequencing method as follows: -Leu-Ala-Leu-Ser-Lys-Gln-Ile-Gln-Ile-Ala-.
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