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目的探索年龄小于50岁患者的血尿酸与冠心病的关系。方法收集近3年间经冠脉造影证实为冠心病患者与非冠心病患者的临床资料,包括性别、年龄、血尿酸、血糖、血脂、体重指数、冠脉造影结果等,分析两组之间血尿酸水平;多元回归方法分析血尿酸与冠心病的关系。结果冠心病组血尿酸水平明显高于非冠心病组(P=0.003)。冠心病双支和多支病变的患者血尿酸水平均高于明显单支病变(P<0.05;P<0.01)。多元组步回归分析证实在调整了其他危险因素外,血尿酸与冠心病病变严重程度密切相关(P=0.005)。结论血尿酸升高是50岁以下冠心病患者的独立危险因素。
Objective To explore the relationship between serum uric acid and coronary heart disease in patients younger than 50 years old. Methods The clinical data including coronary heart disease and coronary heart disease confirmed by coronary angiography in recent 3 years were collected, including gender, age, serum uric acid, blood glucose, blood lipid, body mass index and coronary angiography. Uric acid levels; multiple regression analysis of the relationship between uric acid and coronary heart disease. Results The level of serum uric acid in CHD group was significantly higher than that in non-CHD group (P = 0.003). The level of serum uric acid in patients with double-vessel coronary disease and multiple vessel disease were significantly higher than those with obvious single vessel disease (P <0.05; P <0.01). Multivariate stepwise regression analysis confirmed that the adjustment of other risk factors, blood uric acid and coronary heart disease severity is closely related (P = 0.005). Conclusion The elevated serum uric acid is an independent risk factor for coronary heart disease in patients under 50 years of age.