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目的探讨子宫内膜异位症腹腔镜术后应用促性腺激素释放激素激动剂(Gn RHa)联合反加疗法的疗效。方法 74例行腹腔镜手术治疗的子宫内膜异位症患者,根据术后治疗方案分为观察组和对照组,各37例。对照组患者采用Gn RHa治疗,观察组患者采用Gn RHa联合反加疗法治疗,比较两组患者的病症缓解情况、预后情况、血清性激素水平的改变情况、不良反应情况。结果治疗后,两组患者卵泡刺激素、黄体生成激素、雌二醇均显著下降(P<0.05)。观察组雌二醇明显高于对照组,不良反应发生率明显低于对照组,差异均有统计学意义(P<0.05)。观察组卵泡刺激素、黄体生成激素、病症完全缓解率、术后妊娠率、累计复发率与对照组比较,差异无统计学意义(P>0.05)。结论子宫内膜异位症腹腔镜术后应用Gn RHa联合反加疗法可明显改善患者的临床病症和预后状况,可有效预防低雌激素病症,不良反应少且安全性高,值得临床推广。
Objective To investigate the effect of GnRa combined with anti-addictive therapy after laparoscopic endoscopic surgery for endometriosis. Methods Seventy-four patients with endometriosis undergoing laparoscopic surgery were divided into observation group and control group according to the postoperative treatment regimen, 37 cases in each group. The patients in the control group were treated with Gn RHa. The patients in the observation group were treated with Gn-RHa combined with anti-addiction therapy. The symptoms, the prognosis, the changes of serum sex hormone levels and the adverse reactions were compared between the two groups. Results After treatment, follicle-stimulating hormone, luteinizing hormone and estradiol decreased significantly in both groups (P <0.05). The estradiol in the observation group was significantly higher than that in the control group, and the incidence of adverse reactions was significantly lower than that in the control group (P <0.05). The observation group follicular stimulating hormone, luteinizing hormone, disease complete remission rate, postoperative pregnancy rate, the cumulative recurrence rate compared with the control group, the difference was not statistically significant (P> 0.05). Conclusions After laparoscopic endoscopic treatment of endometriosis combined with Gn RHa anti-addictive therapy can significantly improve the patient’s clinical conditions and prognosis, which can effectively prevent low estrogen disorders, fewer adverse reactions and high safety, worthy of clinical promotion.