Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC

来源 :药物分析学报:英文版 | 被引量 : 0次 | 上传用户：pingguotailang

【摘要】

：

5-Fluorouracil(5-FU)is an anticancer drug extensively used for different cancers.Intracellular metabolic activation leads to several nucleoside and nucleotide m

【作者】

：

Christelle Machon Frederic Cat

【机构】

：

LaboratoiredeChimieAnalytique,LaboratoiredeBiochimieetdePharmaco-toxicologie,InsermU1052,Institutdes

【出处】

：

药物分析学报:英文版

【发表日期】

：

2021年1期

【关键词】

：

5-FLUOROURACIL LC-MS-HRMS NUCLEOTIDE RNA DNA Incorporation rate

【基金项目】

：

supported by Institut National Du Cancer(grant number 2018-131).

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5-Fluorouracil(5-FU)is an anticancer drug extensively used for different cancers.Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzym

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