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目的:探讨应用人重组粒细胞集落刺激因子(rh G-CSF)宫腔灌注治疗复发性流产(RSA)患者妊娠结局的影响。方法:早期RSA患者100例,随机分为rh G-CSF研究组(n=56)和生理盐水对照组(n=44),于围排卵期行宫腔灌注治疗3 d,连续2个周期,前瞻性比较研究组和对照组患者继续妊娠率和流产率,子宫内膜厚度、基底回声等血流动力学指标。结果:与对照组相比,研究组继续妊娠率高于对照组(88.87%vs 60.60%,P<0.05),流产率低于对照组(11.11%vs 39.39%,P<0.05);围排卵期内膜厚度组间无统计学差异(P>0.05),研究组宫腔灌注治疗后内膜基底区回声优于对照组,差异有统计学意义(P<0.05);内膜下血流分支呈增加趋势(P>0.05)。结论:rh G-CSF宫腔灌注改善RSA患者的子宫内膜容受性,降低流产率。
Objective: To investigate the effect of intrauterine perfusion of rhG-CSF on pregnancy outcomes in patients with recurrent spontaneous abortion (RSA). Methods: One hundred patients with early RSA were randomly divided into two groups: rhG-CSF group (n = 56) and saline control group (n = 44) Sexual comparison study group and control group patients continued pregnancy rate and abortion rate, endometrial thickness, basal echo and other hemodynamic parameters. Results: Compared with the control group, the pregnancy rate of the study group was higher than that of the control group (88.87% vs 60.60%, P <0.05), and the abortion rate was lower than that of the control group (11.11% vs 39.39%, P <0.05) There was no significant difference in intima thickness between the two groups (P> 0.05). The echogenicity of basilar zone of endometrial in the study group was better than that of the control group (P <0.05) Increase trend (P> 0.05). Conclusion: Intrauterine rhG-CSF infusion improves endometrial receptivity and reduces abortion rate in RSA patients.