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[目的]观察多房囊性肾细胞癌(MCRCC)免疫组化染色特征,并与透明细胞性肾细胞癌(CCRCC)进行比较。[方法]收集10例MCRCC和12例低核级的CCRCC,应用免疫组化Envision方法检查常用的肾肿瘤诊断标志物CK7、CD10、P504s、Vimentin、EMA、Cam5.2和PAX8在两者之间的表达情况并进行比较分析。[结果]MCRCC中,80.0%表达CK7,40.0%表达CD10,30.0%表达P504s,50.0%表达Vimentin,100.0%表达EMA、Cam5.2和PAX8。CCRCC中,16.7%表达CK7,91.7%表达CD10,25.0%表达P504s,58.3%表达Vimentin,100.0%表达EMA、Cam5.2和PAX8。MCRCC与CCRCC的免疫组化特征比较,CK7在前者的表达率明显较高(P<0.05),而CD10在前者的表达率明显较低(P<0.05),P504s、Vimentin、EMA、Cam5.2和PAX8等标志物在两者之间的表达率无明显差别(P>0.05)。[结论]MCRCC是一种组织学上独特的低级别肾肿瘤,免疫组化染色特征虽不同于CCRCC,但两者之间存在明显的重叠,组织形态学特征是鉴别诊断两者最重要的标准。
[Objective] To observe the characteristics of immunohistochemical staining of multilocular cystic renal cell carcinoma (MCRCC) and compare it with that of clear cell renal cell carcinoma (CCRCC). [Methods] Ten cases of MCRCC and 12 cases of low-grade CCRCC were collected. Immunohistochemical Envision method was used to examine CK7, CD10, P504s, Vimentin, EMA, Cam5.2 and PAX8 The expression of the situation and comparative analysis. [Results] In MCRCC, 80.0% expressed CK7, 40.0% expressed CD10, 30.0% expressed P504s, 50.0% expressed Vimentin and 100.0% expressed EMA, Cam5.2 and PAX8. In CCRCC, 16.7% expressed CK7, 91.7% expressed CD10, 25.0% expressed P504s, 58.3% expressed Vimentin, 100.0% expressed EMA, Cam5.2, and PAX8. Compared with CCRCC, the expression of CK7 in the former was significantly higher (P <0.05), while the expression of CD10 in the former was lower (P <0.05), P504s, Vimentin, EMA, Cam5.2 There was no significant difference in the expression rates of PAX8 and other markers between the two (P> 0.05). [Conclusion] MCRCC is a histologically unique low-grade renal tumor. Although immunohistochemical staining is different from CCRCC, there is a clear overlap between the two. Histomorphology is the most important criterion for differential diagnosis .