论文部分内容阅读
用PCR变性梯度凝胶电泳法研究载脂蛋白J基因外显子2和5的多态性,发现31例2型糖尿病(T2DM)病人的外显子5的突变杂合子频度高于正常对照(n=30)(100%vs77%,P<0.05),外显子2的突变杂合子频度也高于正常对照(61%vs40%)。提示这种突变可能与T2DM有关。
The polymorphisms of exon 2 and 5 of apolipoprotein J gene were studied by PCR denaturing gradient gel electrophoresis. The frequency of mutation heterozygote of exon 5 in 31 patients with type 2 diabetes mellitus (T2DM) was higher than that of the normal control (n = 30) (100% vs77%, P <0.05). The mutation frequency of exon 2 was also higher than that of the normal control (61% vs 40%). Suggesting that this mutation may be related to T2DM.