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在现有防制疟疾的措施中,化学治疗传统地保持着它的重要地位。恶性疟原虫对4—氨基喹啉类抗性的发展,已引起了人们的重视,要求认真地考虑有关适当使用老药和新药的许多问题。在本文报告中具体地论及了以下的课题:(1)4—氨基喹啉类在疟疾的预防和治疗中仍可起的重要作用;(2)改进了的估价疟原虫对药物反应的技术;(3)对目前4—氨基喹啉类抗性的地理分布的正确的评价;(4)目前评
Among the existing measures against malaria, chemotherapy has traditionally maintained its importance. The development of 4-aminoquinoloid resistance in P. falciparum has drawn much attention and calls for serious consideration of many of the issues related to the proper use of old and new drugs. The following topics are specifically addressed in this report: (1) the important role 4-aminoquinolines can play in the prevention and treatment of malaria; (2) improved techniques for evaluating the response of malaria parasites to drugs ; (3) the correct assessment of the current geographical distribution of 4-aminoquinoline resistance; (4) the current assessment