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胰腺癌仅占恶性肿瘤的2%,却占癌症死亡的第4位.迄今为止,胰腺癌的切除率从未超过20%,五年生存率低于5%.对胰腺癌采取多模式综合治疗,虽有一定的疗效,也远不令人满意.随着分子生物学研究的深入,对胰腺癌采用基因治疗给我们展示了新的前景,是胰腺癌当代治疗的一个重要方面.广大学者也一直在不断的探索有效的治疗途径,本文试从以下几个方面综述胰腺癌基因治疗近年研究进展.1 WTp53基因替代疗法p53基因是目前明确的最容易产生突变的抑癌基因,突变的p53不仅失去正常野生型 p53(WTp53)的生长抑制作用,
Pancreatic cancer accounts for only 2% of malignant tumors, but it is the fourth leading cause of cancer deaths, and so far the resection rate of pancreatic cancer has never exceeded 20% and the 5-year survival rate is less than 5% , Although a certain effect, but also far from satisfactory.With the deepening of molecular biology, the use of gene therapy for pancreatic cancer shows us a new prospect for contemporary treatment of pancreatic cancer is an important aspect of the majority of scholars In this paper, we review the recent progress of pancreatic cancer gene therapy in the following aspects.1 The p53 gene of WTp53 gene is the most obvious tumor suppressor gene that is easy to produce mutation at present, and the mutant p53 not only Lost the growth inhibition of normal wild-type p53 (WTp53)