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目的探讨HLA-B27/B7抗原检测在诊断强直性脊柱炎(AS)中的临床价值。方法选取144例门诊及住院高度疑似AS的患者,应用流式细胞仪对其标本进行HLA-B27/B7抗原检测。结果HLA-B27抗原阳性率在青少年人群比较高,且男性显著高于女性,受检的144例患者,HLA-B27抗原阳性率为63.9%,低于确诊为AS的阳性率(91.1%)。HLA-B27抗原检测对诊断AS的灵敏度为91.1%(82/90),特异度为81.5%(44/54),正确率为87.5%(126/144)。结论 HLA-B27抗原与AS密切相关,对临床诊断AS很有帮助,用流式细胞术进行检测是较好的方法。
Objective To investigate the clinical value of HLA-B27 / B7 antigen in the diagnosis of ankylosing spondylitis (AS). Methods A total of 144 outpatients and patients with suspected AS in hospital were enrolled in this study. HLA-B27 / B7 antigen was detected by flow cytometry. Results The positive rate of HLA-B27 antigen in adolescents was higher than that in women. The positive rate of HLA-B27 antigen was 63.9% in 144 patients, which was lower than the positive rate of 91.1%. The sensitivity of HLA-B27 antigen detection to the diagnosis of AS was 91.1% (82/90), specificity was 81.5% (44/54), and the correct rate was 87.5% (126/144). Conclusion HLA-B27 antigen is closely related to AS, which is helpful for clinical diagnosis of AS. Flow cytometry is a better method.