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HBV的4个亚基因产物中,HBx具有反式激活、介导细胞凋亡作用,HBs具有反式激活因子的作用。肝细胞癌(HCC)的发生与HBV的整合及整合后染色体重排有关。为探讨HBV整合及HBx、HBs亚基因在HCC发生中的可能作用,我们制备了HBV亚基因探针,并以此对肝细胞癌中HBV整合及亚基因转录进行了
Of the four subunit products of HBV, HBx has transactivation and mediates apoptosis, and HBs has the function of transactivator. The occurrence of hepatocellular carcinoma (HCC) is related to the integration of HBV and the integration of chromosomal rearrangements. To explore the possible role of HBV integration and HBx, HBs subunits in the development of HCC, we prepared HBV subgenomic probes and performed HBV integration and sub-gene transcription in hepatocellular carcinoma