研究目的探讨苯酞类天然产物的合成方法及其生物活性。研究方法以邻苯二甲酐为底物，首先引入丁烯基，再进行烯丙位氧化，制得目标化合物。结果通过丁基锂反应，得到了具有药物活性的丁烯基苯酞，然后利用SeO2烯丙位氧化，首次合成了Z－3－（2－羟基丁烯基）苯酞。结论此合成方法原料易得，方法简便，为苯酞类化合物的合成研究提供了一个新的途径。 The purpose of this study was to investigate the synthesis and biological activity of phthalides. Research methods phthalic anhydride as a substrate, the first introduction of butenyl, then allylic oxidation, the target compound. Results By the reaction of butyllithium, the pharmacologically active butenylphthalide was obtained. Then, Z-3- (2-hydroxybutenyl) phthalide was synthesized for the first time by the oxidation of SeO2. Conclusion The synthesis method is easy to get raw materials, the method is simple, and provides a new way for the synthesis of phthalides.